Basic-patch mutations in bacteriophage T4 Rad50 uncouple ATPase activation from processive nuclease activity
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The Mre11/Rad50 (MR) complex uses ATP binding and hydrolysis to coordinate the recognition and processing of DNA double-strand breaks. Although Mre11 and DNA stimulate the relatively slow ATPase activity of Rad50, the mechanism by which this occurs remains inc... ...
