Interplay between Na+/K+-ATPase-dependent Src-mediated Ca2+ sensitization and BKCa channel negative feedback regulates rat mesenteric artery contraction
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The Na+/K+-ATPase α2 isoform regulates vascular tone by modulating Na+/Ca2+ exchange and Src kinase-dependent signaling within membrane microdomains. Inhibition of the Na+/K+-ATPase by cardiotonic steroids promotes vascular contraction through increased intra... ...
