Irisin Potentiates 5-fluorouracil Cytotoxicity in HT-29 Colon Cancer Cells through Enhanced Apoptosis and Transcriptional Modulation of Adenosine Monophosphate-activated Protein Kinase/Mammalian Target of Rapamycin Signaling
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Background: Although 5-fluorouracil (5-FU) is a standard chemotherapeutic agent for colorectal cancer (CRC), its efficacy is often limited by chemoresistance. Irisin, an exercise-induced myokine, has demonstrated anticancer poten... ...
