Modeling Inherited Methylmalonic Acidemia Using Isogenic Human Induced Pluripotent Stem Cell-Derived Hepatocytes with Mutations in Methylmalonyl-CoA Mutase
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Isolated methylmalonic acidemia (MMA) is an autosomal recessive disorder that increases methylmalonic acid by affecting the metabolism of propionyl-CoA. Mutations in multiple genes cause MMA, however, those in methylmalonyl-CoA mutase ( MMUT ) are most common.... ...
