Overexpression of EZH2 is associated with clinicopathological parameters and poor prognosis in gliomas
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The histone methyltransferase enhancer of zeste homolog 2 (EZH2), which is primarily localized in the nucleus, mediates Polycomb repressive complex activity by trimethylating lysine 27 of histone H3 (H3K27me3), thereby leading to transcriptional silencing. EZH... ...
