Design and engineering of μO-conotoxin MfVIA mutants to enhance NaV1.8 inhibition and analgesic efficacy in inflammatory pain
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Voltage-gated sodium (NaV) channels are essential for action potential initiation and propagation and play key roles in pain signaling. NaV1.8 is predominantly expressed in nociceptors and drives persistent sodium currents that support repetitive firing, makin... ...
