An activating mutation in AGEF-1, a putative Arf GEF, causes yolk extrusion from C. elegans embryos
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C. elegans AGEF-1 , an ortholog of human ARFGEF1 and ARFGEF2, functions with ARF-1 , ARF-5 and the AP-1 clathrin adaptor to regulate membrane trafficking. Similar phenotypes induced by the agef-1 ( vh4 [E1028K]) allele and agef-1 (RNAi) suggested that agef-1 (... ...
