Conditional Knockout of Indoleamine 2, 3-Dioxygenase-1 in Osteoprogenitor Cells in Mice Results in Sex-dependent Differences in Bone Mass
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Tryptophan is an essential amino acid metabolized in the body primarily through enzymatic degradation involving indoleamine and tryptophan 2,3-dioxygenase (IDO and TDO), generating kynurenine as the initial step, and ultimately leads to multiple bioactive meta... ...