Coral-inspired immunoreprogramming scaffold reverses the "immune-freeze" microenvironment to promote bone regeneration in steroid-induced osteonecrosis of the femoral head
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The core pathological mechanism of steroid-induced osteonecrosis of the femoral head (SONFH) is an "immune freeze" microenvironment-where corticosteroids continuously drive macrophages toward a pro-inflammatory M1 phenotype, inhibiting the conversion to repa... ...
