Coumarin-sulfonamide hybrids as PKM2 activators induce metabolic reprogramming and suppress ovarian cancer cell growth
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Coumarin-piperazine sulfonamides (CPS series) were rationally designed as hybrid modulators of pyruvate kinase M2 (PKM2) to exploit metabolic vulnerabilities in ovarian cancer. Phenotypic screening across cancer cell lines guided hit identification, and molecu... ...
