Beyond the catalytic site: Voxilaprevir and Pasireotide as repurposed therapeutics for conformational inhibition of ADAR1
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Adenosine deaminase acting on RNA 1 (ADAR1) is a central regulator of tumor immune evasion, suppressing innate immune sensing of endogenous double-stranded RNA (dsRNA) through adenosine-to-inosine (A-to-I) editing. Despite its therapeutic potential, inhibitor ... ...
