Therapeutic targeting of COX-2 in head and neck cancer: Mechanistic and clinical perspectives
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Cyclooxygenase-2 (COX-2) is a key player in inflammation; it is often over-activated in HNSCC, which consequently increases the levels of prostaglandin E2 (PGE2) (an inflammatory mediator) leading to tumor proliferation, angiogenesis, epithelial-mesenchymal tr... ...
