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The factors between BMI and diabetic nephropathy and protective role of the FGF21-SIRT1 axis in diabetic nephropathy

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Obesity and diabetic nephropathy (DN) represent escalating global health burdens. Glomerular mesangial cell (MC) injury, driven by lipotoxicity from free fatty acids like palmitic acid (PA), is central to DN pathogenesis. Fibroblast growth factor 21 (FGF21) re... ...