Cryo-EM analysis of cooperative conformational changes in the SARS-CoV-2 spike protein trimer
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The entry of SARS-CoV-2 into cells is mediated by a trimeric spike protein that utilizes its receptor-binding domain (RBD) to engage with the cell surface receptor ACE2, with each protomer capable of shuttling between an `up' conformation that can bind ACE2 a... ...
