A multi-Level Study of 20S proteasome inhibitors: an integrated approach combining chemistry and Modelling
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In view of the important role of 20S proteasome inhibitors in the treatment of multiple myeloma, a 2D-QSAR study was developed using the Monte Carlo approach for 41 peptide boronic acids (PBA) characterised by the CT-L activity of the human 20S proteasome. The... ...
