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Znrf2-mediated ST2L degradation limits IL-33/ST2L anti-fibrotic signaling and promotes post-infarction cardiac fibrosis

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Myocardial infarction (MI) remains a major cause of heart failure, largely driven by maladaptive ventricular remodeling and excessive cardiac fibrosis. The IL-33/ST2L axis exerts cardioprotective and anti-fibrotic effects, but how the availability of the membr... ...