Carborane Hydrophobic Tags Drive Selective Degradation of Endogenous KRASG12C via HSP70-Ubiquitin-Proteasome Pathway
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Persistent activation of the Kirsten rat sarcoma viral oncogene homologue (KRAS)G12C mutation sustains oncogenic signaling, and covalent inhibitors often yield incomplete pathway suppression or resistance. Herein, we developed hydrophobic-tag (HyT) degraders b... ...
