Progressive suppression of DNA repair genes with persistent p53 target activation in doxorubicin-treated cardiomyocytes
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Doxorubicin (DOX) is an effective anticancer drug; however, it can cause cardiotoxicity by inducing DNA double-strand breaks in cardiomyocytes. Cardiotoxicity can manifest immediately or years following treatment. Most human in vitro models of DOX-induced card... ...
