A morphology-driven proof-of-concept study linking interphase nuclear abnormalities to dicentric-mediated genomic instability
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Genomic instability is a major driver of clinical heterogeneity and treatment resistance in B-cell malignancies. In chronic lymphocytic leukemia (CLL) complex karyotype (CK) and disruption of the TP53 pathway are key markers of poor prognosis. Here we investig... ...
