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An antioxidant therapy elicits distinct transcriptome responses in 22q11-deleted upper layer cortical projection neurons

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We characterized in vitro and in vivo responses to the antioxidant N-acetyl cysteine (NAC), which in the 22q11.2 Deletion Syndrome LgDel mouse model restores growth and connectivity of developing upper layer cortical projection neurons (Layer 2/3 PNs) and impr... ...