The design of a small Bayesian hybrid-controlled trial utilizing time-to-event data from six published sources that used best alternative care to treat liver-predominant metastasis from primary ocular melanoma
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Background: Time-to-event endpoints, such as progression-free survival (PFS), are used to evaluate clinical activity in early-phase RCTs in cancer research. Because the power to detect a reduction in the hazard rate depends on th... ...
