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The multi-omics landscape of lung adenocarcinoma evolution: deciphering metabolic reprogramming-driven immune escape and its implications in combined therapy

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The progression of lung adenocarcinoma (LUAD) from pre-invasive lesions (atypical adenomatous hyperplasia/adenocarcinoma in situ) to invasive adenocarcinoma constitutes a complex, multi-dimensional, and dynamic process. While the genomic drivers underlying thi... ...