Intercepting the SOS message: SpsB inhibition by OXF-077 stalls the evolution of antibiotic resistance
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In this issue of Cell Chemical Biology, Bradbury et al.1 identify signal peptidase IB (SpsB) as the cellular target of the SOS-response inhibitor OXF-077. This uncovers an unexpected role for SpsB in bacterial mutagenesis, highlighting its potential as an extr... ...
