Dangerous liaisons: Promiscuous inhibition of CHK1 and AMPK is a lethal affair for cancer cells
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In this issue of Cell Chemical Biology, Guo et al.1 reveal that the Checkpoint kinase 1 (CHK1) inhibitor Prexasertib moonlights as an AMP-activated protein kinase (AMPK) inhibitor that primes cancer cells for destruction. This off-target synergy highlights tha... ...
