Development and Validation of Sensitive RP-HPLC Bioanalytical Method of Diclofenac Sodium and Its Predictive In-Silico Physiologically Based Pharmacokinetic Modeling in Hepatic and Renal Impairment
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Diclofenac sodium is a widely prescribed NSAID for inflammatory and rheumatoid diseases, and the dose adjustment, especially for elderly patients suffering from renal or hepatic impairment, is not a routine practice. In this study, a sensitive RP-HPLC bioanaly... ...
