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Attention-guided and MIL-constrained CycleGAN for high-fidelity virtual p16 and Ki-67 staining

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Cervical intraepithelial neoplasia (CIN) grading relies on both morphological assessment from hematoxylin and eosin (H&E) slides and biomarker expression from immunohistochemistry (IHC), such as p16 and Ki-67. However, conventional IHC staining is time-consumi... ...