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IgA nephropathy: a novel pathway in immunopathogenesis dependent on the timing of Epstein-Barr virus infection

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IgA nephropathy (IgAN) is an autoimmune disease in which polymeric IgA1, with joining (J) chain and altered glycosylation of the hinge region (HR), acts as an autoantigen recognized by naturally occurring IgG antibodies, resulting in generation of nephritogeni... ...