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Severe renal toxicity following adjuvant envafolimab in a patient with ultra-hypermutated (POLE) stage II colorectal cancer: a case report

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Background: POLE-mutated colorectal cancer (CRC) is a rare molecular subtype featured by ultra-high tumor mutational burden (TMB) and favorable prognosis, and adjuvant systemic therapy is generally not recommended for such patien... ...