Inactive β1-integrin acts as a junctional scaffold for angiopoietin/TIE2/FOXO1 signaling
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The blood and lymphatic vascular systems are regulated by angiopoietin (ANGPT) growth factors, which signal via endothelial TIE receptor tyrosine kinases and integrins. However, mechanistic understanding of how these receptors crosstalk is limited. Here, we sh... ...