Design and synthesis of 7-chloroquinoline-derivative-bearing urea, carbamate, or thiourea moieties and their antimalarial activity against Plasmodium berghei via the inhibition of β-hematin formation
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We describe a short synthetic route to a new series of 7-chloroquinoline hybrids derived from albendazole-, thioacetazone-, and primaquine-based drugs. The design strategy incorporated a ureido group as a bioisostere of known inhibitors of β-hematin formation... ...
