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Increased head-turning, hyperactivity and low-penetrance circling behaviour in mice lacking ZPLD1, a protein that scaffolds the cupula to the roof of the ampulla

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The study aims to understand how loss of ZPLD1 affects the behaviour of homozygous Zpld1(em1/IMPC)J mice (Zpld1-/- mice) and the structure of the cupula. Evaluation of 2-minute open-field, swim, and tail-suspension tests indicated open-field testing was optima... ...