HDAC4 regulates hASC osteogenesis and bone regeneration by mediating SMAD4 via histone acetylation
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Craniofacial large bone defects possess limited self-repair capacity. This study identifies histone deacetylase 4 (HDAC4) as a key epigenetic repressor of osteogenesis in human adipose-derived stem cells. Inhibiting HDAC4, either genetically or pharmacological... ...
