In vitro reversible enzyme inhibition assays to predict drug-drug interactions: Current state and industry perspective from the IQ Consortium Enzyme Inhibition Working Group
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Inhibition of drug-metabolizing enzymes such as P450s and uridine 5'-diphosphoglucuronosyltransferase is routinely evaluated in drug discovery and development. Substantial efforts have been made over the years to standardize in vitro assay conditions and data... ...
