Effects of Celecoxib and Etoricoxib on the Pharmacokinetics and Pharmacological Effects of Orally Administered Tramadol: A Randomised Controlled Trial
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Tramadol is a widely used analgesic whose bioactivation to O-desmethyltramadol is primarily mediated by cytochrome P450 2D6 (CYP2D6). Genetic variability and drug-drug interactions affecting CYP2D6 may influence tramadol pharmacokinetics and pharmacological ef... ...
