REGULATORY GENE ANALYSIS IN ENTERIC NEURAL CREST CELLS STRATIFIED BY GDNF ACTIVATION STATUS: AN INSIGHT INTO HIRSCHSPRUNG DISEASE PATHOPHYSIOLOGY
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Background: Incomplete migration of enteric neural crest cells (ENCCs) into the colon underlies the pathogenesis of Hirschsprung disease, resulting in aganglionosis and disordered intestinal motility. Although activation of the g... ...
