Revisiting 2-Substituted-4(1 H)-Quinolones for Targeting the Plasmodium falciparum Cytochrome bc1 Complex
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Quinolones substituted at the 2- and 3-positions with biaryl and diphenylether groups have been investigated for their antimalarial potential. ELQ-300, with a 3-position diphenyl ether, is at an advanced stage of preclinical development. Here, we synthesize th... ...
