Characterization and functional analysis of FruR in Streptomyces lincolnensis: A pleiotropic regulator that links fructose metabolism to lincomycin biosynthesis
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Lincomycin, a clinically important lincosamide antibiotic, is primarily produced by Streptomyces lincolnensis. This study demonstrated that fructose supplementation inhibits lincomycin biosynthesis. Gene function analysis and gene knockout experiments revealed... ...
