ST-LDAW: A Topic-Model and Damped Weighted Least-Squares Method for Integrative Deconvolution of Single-Cell and Spatial Transcriptomics
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Integrating single-cell RNA sequencing (scRNA-seq) with spatial transcriptomics (ST) enables the projection of cell-type-resolved transcriptional programs onto tissue architecture. However, existing integration methods are often unstable because spot-level inf... ...
