Alpha-2 antiplasmin deficiency: a rare fibrinolytic disorder identified after decades of diagnostic delay
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Alpha-2 antiplasmin (α2AP) deficiency is a rare fibrinolytic disorder characterized by unregulated plasmin activity and premature clot breakdown. Mechanistically, α2AP restrains fibrinolysis by (i) forming a covalent serpin complex with plasmin, (ii) blockin... ...
