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Wnt5b/FZD1/LRP6 signaling drives renal fibrosis by triggering cytoplasmic stabilization and nuclear translocation of β-catenin under hypoxia

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Hypobaric hypoxia, a unique environmental feature of high-altitude areas, is associated with kidney disease, but the mechanism remains unclear. In this study, blood and urine samples from high-altitude volunteers are examined, revealing that high-altitude hypo... ...