Loss of the mechanistic target of rapamycin complexes 1 (mTORC1) causes a lethal alpha-1 antitrypsin deficiency associated liver disease
{{output}}
Background & aims: SERPINA1 mutations cause retention of the otherwise secreted alpha-1 antitrypsin (AAT) and lead to the proteotoxic AAT deficiency (AATD)-related liver disease (AATD-LD). As mechanistic target of rapamycin (mTOR... ...
