A Model-Informed Early Prediction of Methotrexate-Induced Acute Kidney Injury in Pediatric Patients with Osteosarcoma Using Real-World Data: A Multi-center Pharmacokinetic Study
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Background and objective: High-dose methotrexate is central to pediatric osteosarcoma treatment, but delayed elimination increases the risk of acute kidney injury, compromising treatment intensity. Current therapeutic drug monito... ...
