Use it or lose it: A ubiquitin-mediated autophagy pathway for degradation of MHC-I in pancreatic cancer
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In this issue of Molecular Cell, Berquez et al.1 reveal that MHC-I is degraded from within the endoplasmic reticulum (ER) by a ubiquitin-driven autophagy pathway involving co-operation of a cytoplasmic and an ER-phagy cargo receptor. ... ...
