RNAP at the apex: Cryo-ET unveils the torsional tango between plasmid DNA and double-helix-melting proteins
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In this issue, Zhang and Cañari-Chumpitaz et al.1 find that RNA polymerase (RNAP) preferentially binds to the apices of supercoiled DNA plectonemes, which facilitates promoter escape but imposes a torsional trade-off during elongation. In the presence of tors... ...
