Molecular dynamics-guided design of sulfadiazine-based α-aminophosphonates as DNA gyrase inhibitors with enhanced binding stability and antibacterial activity
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A focused series of six sulfadiazine-based α-aminophosphonate derivatives (M1-M6) was synthesized via the Kabachnik-Fields three-component reaction and evaluated as potential DNA gyrase inhibitors against multidrug-resistant Staphylococcus aureus (MRSA) and P... ...
