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MEF2A/KMT2D/H3K4me3/LOX axis promotes osteoclast differentiation by increasing autophagic flux and participates in LPS-induced osteolysis

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Overactivation of osteoclasts represents the core pathological mechanism driving bone destruction and pathological osteolysis, yet safe and effective targeted therapeutic strategies remain lacking in clinical settings. Lysyl oxidase (LOX), an extracellular mat... ...