Mechanistic Evidence for Gold(III)-Mediated Arylation of the Cys-Sec Motif of Thioredoxin Reductase 1
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Thioredoxin reductase (TrxR) is a well-known target for gold-based drugs, which typically behave as strong inhibitors of this selenoenzyme. Despite recent evidence that cyclometalated Au(III) complexes inhibit TrxR1 and arylate cysteine (Cys)- and selenocystei... ...
