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Recovery of TCRαβ but not TCRγδ CDR3 sequences from ancient human whole-genome sequencing data [v. 22 May 2026]

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The T-cell receptor (TCR) repertoire is a major component of the adaptive immune system that reflects host-pathogen co-evolution. Previous paleogenomic studies have focused primarily on deciphering major histocompatibility complex (MHC) diversity; however, TCR... ...