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USP39 reduces BRCA1 methylation to promote mitochondrial biogenesis and lower drug sensitivity in ovarian cancer through deubiquitinating ZC3H18

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Ovarian cancer (OV) is a leading cause of mortality related to gynecological malignancies. Chemoresistance represents a major clinical obstacle. Carboplatin (CBP) is a first-line chemotherapeutic agent widely used for ovarian cancer treatment. Meanwhile, Zinc ... ...