Enhanced Recombinant Adeno-Associated Virus (rAAV) Biomanufacturing: Design of Experiment (DOE) Enabled Transfection Optimization for Maximum Full Capsid Yield and Robust Scale-Up
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Recombinant adeno-associated virus (rAAV) gene therapies are a promising class of therapeutics. While their production via triple transfection in a single cell line offers flexibility regarding modification of the transgene, it faces significant challenges, pa... ...